Exploring Organelle Dynamics
With a primary emphasis on the biology of microglial cells, our research integrates induced pluripotent stem cell (iPSC) models of neurodegenerative diseases with advanced super-resolution live-cell imaging and organelle proteomics. This multidisciplinary approach aims to elucidate the roles that interactions between membrane-bound and membraneless organelles play in cellular functionality.
Our recent findings have identified a critical biological role for stress granules; these biomolecular condensates act as molecular 'plugs' that stabilize damaged lysosomal membranes. Inspired by this discovery, we aim to further investigate the cellular functions of diverse membrane-condensate interactions and their implications during disease progression.
About Claudio
Claudio completed his PhD at the National University of Córdoba, Argentina, and undertook internships at The Babraham Institute in Cambridge, UK, and EMBL in Heidelberg, Germany. Specializing in innate immunity, neuroscience, and autophagy, he joined the Host-Pathogen Interactions in Tuberculosis Lab at The Francis Crick Institute in 2018, where he secured a competitive Marie Curie/European Respiratory Society Postdoctoral Fellowship. His work there focused on mitochondria-lysosome interactions during M. tuberculosis infection in human macrophages. In March 2024, Claudio became an Assistant Professor at The School of Biological Sciences, Nanyang Technological University, Singapore. He is particularly passionate about live-cell imaging, with his research driven by interests in quantitative cell biology, emphasizing intracellular trafficking and organelle dynamics.
